Journal of cancer research and clinical oncology
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J. Cancer Res. Clin. Oncol. · Dec 2013
ReviewSafety and efficacy of transdermal buprenorphine for the relief of cancer pain.
This study aimed to synthesize the available evidence on the efficacy and safety of transdermal (TD) buprenorphine. ⋯ Transdermal buprenorphine has an increasing role for the relief of cancer pain. Further research in this field is needed. Multicentre studies in this field using a common protocol and strict supervision will be more practicable.
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J. Cancer Res. Clin. Oncol. · Dec 2013
Scaling adult dose and schedule of anticancer agents to children.
Objective of this work was to extend pharmacokinetic scaling theory of the writer for bolus dosing to include the case of constant-rate i.v. dosing over fixed interval so as to allow projection of adult dose and schedule of typically administered anticancer agents to children. ⋯ Basic theory for scaling adult dose and schedule of anticancer agents to children is presented and demonstrated to be plausible in providing insight into existing and proposed pediatric treatment protocols.
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J. Cancer Res. Clin. Oncol. · Dec 2013
A survey of patterns of practice on palliative radiation therapy for bone metastasis in Korea.
The aim of this study was to understand the practice patterns of palliative radiation therapy for bone metastasis in Korea among Korean radiation oncologists by survey and to determine the decision factors affecting the prescription of radiation therapy fractionation schedules. ⋯ Despite the abundant evidence supporting the equivalence of single- and multi-fraction radiation therapy, still, most Korean radiation oncologists continue to prescribe multi-fraction schedules depending on the general performance and life expectancy of the patients. Thus, we confirmed that there was a gap between evidence and practice, and treatment prescriptions can be strongly affected by decision factors other than published literature results.