Journal of cancer research and clinical oncology
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J. Cancer Res. Clin. Oncol. · Mar 2015
Comparative StudyDown-regulation of BTG3 promotes cell proliferation, migration and invasion and predicts survival in gastric cancer.
Gastric cancer (GC) is one of the most common malignancies in China. B-cell translocation gene 3 (BTG3) has been identified as a tumor suppressor in several tumors, but its role in GC remains unknown. This study aimed to detect the expression of BTG3 and its prognostic value in GC tissues and determine its function in the progression of GC. ⋯ Down-regulation of BTG3 is closely associated with proliferation, migration and invasion in GC. It may be a novel prognostic biomarker for GC patients.