Journal of cancer research and clinical oncology
-
J. Cancer Res. Clin. Oncol. · Dec 2016
Severe weight loss during preoperative chemoradiotherapy compromises survival outcome for patients with locally advanced rectal cancer.
In addition to tumor factors, poor nutritional status before and during anti-tumor treatment might compromise prognosis in several types of cancer. This study was done to determine the impact of weight loss during preoperative chemoradiotherapy (CRT) on the survival outcome of patients with locally advanced rectal cancer (LARC). ⋯ Our results demonstrate that SWL during preoperative CRT indeed compromises survival outcome in patients with LARC. Routine nutritional monitoring and nutritional support during preoperative CRT are suggested as the integral part of the multidisciplinary approach for these patients.
-
J. Cancer Res. Clin. Oncol. · Dec 2016
Prognostic value of decreased GRK6 expression in lung adenocarcinoma.
In recent years, G protein-coupled receptor kinases (GRKs) have been implicated in cancer metastasis through phosphorylation of the activated form of G protein-coupled receptors. However, little is known of GRK6 expression in lung adenocarcinoma (LADC) and its potential prognostic value in LADC. ⋯ These findings indicate for the first time that decreased expression of GRK6 may serve as an independent predictor of overall survival in LADC patients.