Indian journal of pharmacology
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To compare the efficacy and safety of gabapentin (GBP), duloxetine (DLX), and pregabalin (PGB) in patients with painful diabetic peripheral neuropathy (DPNP). ⋯ Monotherapy with GBP, DLX, or PGB Produced a clinically and subjectively meaningful pain relief in patients with DPNP with onset of pain relief being faster and superior with PGB.
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The plasma-effect site equilibration rate constant (ke0) of propofol was determined with peak bispectral index (BIS) time (T(PEAK)) in our previous study. The present study has been conducted to evaluate the ke0's performance with effect site-controlled infusion algorithm. ⋯ The study cannot clinically validate the accuracy of application of ke0 derived from the T(PEAK) = 74 s of BIS with Schnider propofol pharmacokinetic model.