Indian journal of pharmacology
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Randomized Controlled Trial Comparative Study
Oxaceprol versus tramadol for knee osteoarthritis: A randomized controlled trial.
To assess efficacy and safety of oxaceprol, a hydroxyproline derivative with putative mechanism of action different from traditional nonsteroidal anti-inflammatory drugs, in symptomatic knee osteoarthritis, in comparison to tramadol. ⋯ Efficacy and tolerability of oxaceprol were comparable to tramadol, and the drug can be considered as an alternative to low-potency opioids in the management of knee osteoarthritis.