Neurological research
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To provide an overview of paraneoplastic nerve hyperexcitability syndromes. ⋯ Nerve hyperexcitability syndrome represents a spectrum of neuroimmunologic diseases, which are often paraneoplastic in etiology.
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Neurological research · Jun 2015
Comparative StudyReliability of the witness descriptions of epileptic seizures and psychogenic non-epileptic attacks: a comparative analysis.
The diagnosis of epilepsy primarily depends on description of the observed seizure. The aim of this study was to determine the reliability of witness' description among groups with different medical education. ⋯ Accurate classification of the attacks is associated with the observers' level of medical knowledge. Witnesses with specific, neurological knowledge with higher probability, compared to the laity and medical students, differentiate ES from PNES.
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Neurological research · Jun 2015
AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain.
The (+)-isomer of indeloxazine AS1069562 has multiple pharmacological actions, such as serotonin (5-HIT) and norepinephrine (NE) reuptake inhibition and analgesic effects in animal models of neuropathic pain. Here, we investigated the analgesic effects of AS1069562 in rat models of inflammatory and noninflammatory nociceptive pain. ⋯ AS1069562 exerts analgesic effects on inflammatory and noninflammatory nociceptive pain in rat models of arthritis pain, and repeated administration of AS1069562 exerts a more persistent analgesic effect on arthritis pain than duloxetine. These findings suggest that AS1069562 has an attractive analgesic profile for the treatment of nociceptive pain.