Neurological research
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Neurological research · Jun 2015
Comparative StudyReliability of the witness descriptions of epileptic seizures and psychogenic non-epileptic attacks: a comparative analysis.
The diagnosis of epilepsy primarily depends on description of the observed seizure. The aim of this study was to determine the reliability of witness' description among groups with different medical education. ⋯ Accurate classification of the attacks is associated with the observers' level of medical knowledge. Witnesses with specific, neurological knowledge with higher probability, compared to the laity and medical students, differentiate ES from PNES.
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Neurological research · Jun 2015
AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain.
The (+)-isomer of indeloxazine AS1069562 has multiple pharmacological actions, such as serotonin (5-HIT) and norepinephrine (NE) reuptake inhibition and analgesic effects in animal models of neuropathic pain. Here, we investigated the analgesic effects of AS1069562 in rat models of inflammatory and noninflammatory nociceptive pain. ⋯ AS1069562 exerts analgesic effects on inflammatory and noninflammatory nociceptive pain in rat models of arthritis pain, and repeated administration of AS1069562 exerts a more persistent analgesic effect on arthritis pain than duloxetine. These findings suggest that AS1069562 has an attractive analgesic profile for the treatment of nociceptive pain.
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Neurological research · May 2015
Multicenter StudyPredictors of neurological deterioration during hospitalization: results from the Chinese Intracranial Atherosclerosis (CICAS) Study.
Neurological deterioration (ND) after ischaemic stroke has been indicated as an independent risk factor for poor outcome. Previous studies have focussed on ND within the first few days after symptom onset, but many patients are likely to experience deterioration outside of this time frame. We aimed to investigate the predictors of ND during hospitalisation. ⋯ Patients with watershed infarcts and MCA or BA stenosis or occlusion should be monitored closely, and various therapeutic strategies should be administered simultaneously to prevent pneumonia during hospitalisation.
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Neurological research · Apr 2015
Hyponatremia is a predictor for poor outcome in Guillain-Barré syndrome.
To evaluate the incidence and prognostic value of hyponatremia in patients with Guillain-Barré syndrome (GBS) in northern China. ⋯ Hyponatremia is an important predictor of poor outcome in GBS patients.
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Brain-derived neurotrophic factor (BDNF) is a member of neurotrophins family that plays a pivotal role in memory and learning. Brain-derived neurotrophic factor mediates health benefits of physical activity both in humans and animals. The nerve damage and cognitive impairment in diabetic rats are thought to be the result of reduced BDNF levels. The purpose of this study was to examine the effect of short- and long-term moderate forced exercise on BDNF levels in the hippocampus of type 1 diabetic rats. ⋯ It was shown that spatial memory was improved by the exercise protocol, while the BDNF levels did not change significantly in any group. As a BDNF secretion in the brain is dependent on running paradigm factor, the protocol chosen might not be intensive or long enough to increase the BDNF levels. Exercise may improve spatial memory in type 1 diabetic rats in a way that BDNF is not included.