Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Nov 1997
Randomized Controlled Trial Multicenter Study Clinical TrialEffectiveness of norgestimate and ethinyl estradiol in treating moderate acne vulgaris.
An excess of androgen is believed to contribute to development of acne in some patients. Because oral contraceptives (OCs) may reduce the active androgen level, hormonal therapy with OCs has been used successfully to treat patients with acne, although this treatment has previously not been studied in placebo-controlled trials. ⋯ An OC containing 0.035 mg of ethinyl estradiol combined with the triphasic regimen of norgestimate is a safe and effective treatment of moderate acne vulgaris in women with no known contraindication to OC therapy.
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J. Am. Acad. Dermatol. · Nov 1997
Randomized Controlled Trial Clinical TrialUse of eutectic mixture of local anesthetics: an effective topical anesthetic for slit-smear testing of patients with Hansen's disease.
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J. Am. Acad. Dermatol. · Nov 1997
Case ReportsTarget lesions on the lips: childhood herpes simplex associated with erythema multiforme mimics Stevens-Johnson syndrome.
Erythema multiforme and Stevens-Johnson syndrome are both characterized by areas of epithelial necrosis. An important clinical feature that distinguishes the two is the extensive mucosal necrosis in Stevens-Johnson syndrome but not in erythema multiforme. ⋯ We describe three boys with herpes simplex virus-associated erythema multiforme who had severe necrosis of the lips develop and were initially diagnosed with Stevens-Johnson syndrome. The lip lesions were large target lesions of erythema multiforme rather than the extensive necrosis seen in Stevens-Johnson syndrome and all three had a benign course.