Journal of the American Academy of Dermatology
-
J. Am. Acad. Dermatol. · Jun 2003
Randomized Controlled Trial Clinical TrialReduction in injection pain with botulinum toxin type B further diluted using saline with preservative: a double-blind, randomized controlled trial.
Injection with botulinum A exotoxin reconstituted with preserved saline has been shown to be less uncomfortable than injection with the same toxin reconstituted with preservative-free saline. ⋯ Use of preservative-containing saline to further dilute botulinum toxin type B can significantly decrease patient discomfort on injection.
-
J. Am. Acad. Dermatol. · Jun 2003
Case ReportsErythromelalgia precipitated by acral erythema in the setting of thrombocytopenia.
Erythromelalgia is a rare syndrome that is characterized by episodic attacks of burning pain in the distal extremities, which last from minutes to days and are precipitated by exercise, warmth, or limb dependency. There is a primary or idiopathic form and a secondary form that occur with myeloproliferative or other diseases. All previous reports about erythromelalgia that is the result of a myeloproliferative process have documented associated thrombocytosis. We describe a 40-year-old woman with myelodysplastic syndrome who experienced erythromelalgia in the setting of acral erythema and thrombocytopenia, first induced by chemotherapy and recurring after a radiation- and chemotherapy-based myeloablative regimen that was administered before a T-cell-depleted allogeneic bone marrow transplantation.