The Journal of infection
-
The Journal of infection · Jan 2014
ReviewAdvances towards the prevention of meningococcal B disease: a multidimensional story.
Whilst much progress has been made in reducing the burden of bacterial meningitis and septicaemia through vaccination, endemic serogroup B meningococcal (MenB) disease has remained problematic. Polysaccharide-protein conjugate vaccines are now available to protect against Haemophilus influenzae type b, Neisseria meningitidis serogroups A, C, Y and W and thirteen serotypes of Streptococcus pneumoniae, but this approach has not been used for MenB. Instead efforts have been made to identify protein antigens which, when used in vaccines, will prevent MenB infection and possibly disease due to other serogroups too. The first such vaccine has recently been licensed.
-
The Journal of infection · Jan 2014
Observational StudyDifferential time to positivity is not predictive for central line-related Staphylococcus aureus bloodstream infection in routine clinical care.
Many physicians rely on differential time to positivity (DTP) when diagnosing catheter-related bloodstream infection (CRBSI). We evaluated whether DTP from routine blood cultures can predict catheter-related Staphylococcus aureus bloodstream infection. ⋯ The low test performance suggests that DTP is not useful in diagnosing CRBSI in routinely obtained blood cultures. Therefore, physicians should not solely rely on DTP and rather promote catheter removal and culture.