Behavioural brain research
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Invariant visual object recognition is the ability to recognize visual objects despite the vastly different images that each object can project onto the retina during natural vision, depending on its position and size within the visual field, its orientation relative to the viewer, etc. Achieving invariant recognition represents such a formidable computational challenge that is often assumed to be a unique hallmark of primate vision. Historically, this has limited the invasive investigation of its neuronal underpinnings to monkey studies, in spite of the narrow range of experimental approaches that these animal models allow. ⋯ Rats, in particular, have been the subjects of several behavioral studies, aimed at assessing how advanced object recognition and shape processing is in this species. Here, I review these recent investigations, as well as earlier studies of rat pattern vision, to provide an historical overview and a critical summary of the status of the knowledge about rat object vision. The picture emerging from this survey is very encouraging with regard to the possibility of using rats as complementary models to monkeys in the study of higher-level vision.
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This study explores how people represent spatial information in order to accomplish a visuo-motor task. To this aim we combined two fundamental components of the human visuo-spatial system: egocentric and allocentric frames of reference and coordinate and categorical spatial relations. Specifically, participants learned the position of three objects and then had to judge the distance (coordinate information) and the relation (categorical information) of a target object with respect to themselves (egocentric frame) or with respect to another object (allocentric frame). ⋯ The possible influence of stimuli characteristics (3D objects vs. 2D images) and delay between learning phase and testing phase (1.5 vs. 5s) was also assessed. Results showed an advantage of egocentric coordinate judgments over the allocentric coordinate ones independently from the kind of stimuli used and the temporal parameters of the response, whereas egocentric categorical judgments were more accurate than allocentric categorical ones only with 3D stimuli and when an immediate response was requested. This pattern of data is discussed in the light of the "perception-action" model by Milner and Goodale [13] and of neuroimaging evidence about frames of reference and spatial relations.
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Comparative Study
Differential effects of oxycodone, hydrocodone, and morphine on the responses of D2/D3 dopamine receptors.
Oxycodone and hydrocodone are opioids which are widely used for pain management and are also commonly misused and abused. The exposure to opioid analgesics has been associated with altered responses of D2-like dopamine receptors (D2DRs). Our recent results suggest that various opioids will differentially modulate the responses of D2DRs. ⋯ Mice pretreated with oxycodone showed significantly greater locomotor supersensitivity to quinpirole than did morphine-pretreated mice, while hydrocodone-pretreated mice showed sensitivity in between that of mice treated with morphine and oxycodone. This finding suggests that various opioids differentially modulate the responses of D2DRs. It provides further evidence supporting of the notion that various opioids carry differential risks to the dopamine reward system.
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Hippocampal pathology has been considered to underlie clinical, functional and cognitive impairments in schizophrenia. While longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive gray matter reduction of the hippocampus during the early phases of schizophrenia (SCZ), very little is known about whether functional connectivity (FC) between the hippocampus and other brain regions also exhibit progressive changes. In this study, resting state functional MRI (fMRI) was used to examine changes in hippocampal connectivity at baseline and follow-up scans comparing 68 patients with first episode SCZ and 62 matched controls. ⋯ Interestingly, longitudinal changes of bilateral hippocampal connectivity with right middle frontal gyrus negatively correlated with positive symptom scores in SCZ. These results provide novel evidence for the progressive changes of FC between hippocampus and other brain regions in SCZ. It further suggests that longitudinal changes of bilateral hippocampal connectivity with right middle frontal gyrus can contribute to the formation and emergence of positive symptom of SCZ.
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Much data suggest that the binding of dynorphin-like peptides to kappa-opioid receptors (KORs) during the administration of and withdrawal from a variety of addictive drugs is aversive and serves to limit the reinforcing properties of those drugs and to enhance tolerance, withdrawal, and the probability of stress-induced relapse. In this study, we examined the role of KORs in mediating opioid withdrawal and its aversive consequences in rats. ⋯ The subsequent finding that administration of nor-BNI 2h following withdrawal did not affect the CPA 2 days later suggested that nor-BNI reduced the CPA in the prior experiment because it reduced the aversive effects of withdrawal, not because it reduced the aversive/anxiogenic effects of the withdrawal chamber at the time of CPA testing. These data indicate that the binding of dynorphin-like peptides to KORs during opioid withdrawal serves to enhance withdrawal and its aversive consequences and suggest that selective KOR antagonists may be useful in reducing these aversive effects and consequent relapse.