Scandinavian journal of rheumatology
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Scand. J. Rheumatol. · Jan 2001
Randomized Controlled Trial Comparative Study Clinical TrialCelecoxib versus diclofenac in the management of osteoarthritis of the knee.
A clinical trial was conducted in 600 patients with OA of the knee to test the hypothesis that the specific COX-2 inhibitor, celecoxib, has equivalent efficacy and a superior tolerability/safety profile when compared to diclofenac, the current worldwide standard of care. ⋯ Celecoxib 200 mg daily is as effective as diclofenac 150 mg daily for relieving signs and symptoms of OA of the knee, including pain, and has a rapid onset of action. However, celecoxib appears to have a superior safety and tolerability profile.
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Scand. J. Rheumatol. · Jan 2001
Transesophageal and transthoracic echocardiography and Doppler-examinations in systemic lupus erythematosus.
To search for cardiac abnormalities in systemic lupus erythematosus (SLE). ⋯ Valve masses and valve thickening--often in combination--are the most frequent structural findings in SLE, occurring more often on the aortic than on the mitral valves. Factors other than antiphospholipid antibodies, medication, hypertension, or coronary heart disease seem to be responsible for this phenomenon. Drugs that modulate inflammation in endo- and pericardial tissue may, at least in part, be responsible for the observed mitral valve calcifications and pericardial fibrosis.