Scandinavian journal of rheumatology
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Scand. J. Rheumatol. · Jul 2017
Randomized Controlled TrialIntra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain.
OnabotulinumtoxinA (onabotA) attenuates peripheral nociceptive transduction and consequently neuronal firing. The aim of this mechanistic study was to evaluate the effect of intra-articular (IA) onabotA in patients with painful knee osteoarthritis (OA). ⋯ Intra-articular onabotA given to patients with nociceptive knee OA reduced pain sensitization together with improvement in pain and function.