Preventive medicine
-
Preventive medicine · May 2012
ReviewImprovement of the lipid profile with exercise in obese children: a systematic review.
The objective of this systematic review was to assess the effectiveness of different physical exercise interventions on the lipid profile (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG)) of obese children. ⋯ The programs based on aerobic exercise (60 min, 3 times/week, ≤75% maximum heart rate) improve the LDL-C and TG concentrations. Moreover, the programs based on combined exercise (≥60 min, >75% maximum heart rate) also improve the HDL-C concentration.
-
Preventive medicine · May 2012
ReviewA global view on the development of non communicable diseases.
For a long time non communicable diseases (NCDs) were discussed as burden of the developed world. Recent alarming data show a reverse trend and a dramatic increase of NCDs in the developing world, in particular in highly populated transition countries. This is true for the main mortality triggering diseases such as CVD, cancer or diabetes. ⋯ This development is multi-factorial and is based on some main trends such as globalization, supermarket growth, rapid urbanization and increasingly sedentary lifestyles. The latter leads to overweight or obesity, which again promotes NCDs similar as high blood pressure, high cholesterol and elevated blood glucose. A high quality diet including functional food or functional ingredients, accompanied by physical activity and a non-smoking policy, is one of the most promising factors in primary and secondary prevention of NCDs.
-
Preventive medicine · May 2012
ReviewIsoflavones as a smart curer for non-alcoholic fatty liver disease and pathological adiposity via ChREBP and Wnt signaling.
Non-alcoholic fatty liver disease (NAFLD) and pathological adiposity has emerged as an important modern disease. Along with this, the requirement for alternative and natural medicine for preventing NAFLD and adiposity has been increasing rapidly and considerably. In this report, we will review the biological effect and mechanisms of soy isoflavones on NAFLD and pathologic adiposity mainly through the novel pathways, de novo lipogenic carbohydrate responsive element binding protein (ChREBP) and anti-adipogenic Wnt signaling. ⋯ Natural compound isoflavones may be useful alternative medicines in preventing NAFLD and pathological adiposity and this action may be partially associated with ChREBP and Wnt signaling.
-
Laudable supportive advances have been made to improve the care of patients with the Acute Respiratory Distress Syndrome (ARDS) but no pharmacologic interventions are known to reduce the high mortality of this disorder once it is established. This commentary discusses some of the challenges that arise in preventing ARDS in at-risk individuals and the likely dependence of this approach on biomarker panels that can be done in real time.
-
Preventive medicine · May 2012
Comparative StudyEffect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats.
The Acute Respiratory Distress Syndrome (ARDS), the most severe form of Acute Lung Injury (ALI), is a highly-fatal, diffuse non-cardiogenic edematous lung disorder. The pathogenesis of ARDS is unknown but lung inflammation and lung oxidative stress are likely contributing factors. Since no specific pharmacologic intervention exists for ARDS, our objective was to determine the effect of treatment with ergothioneine-a safe agent with multiple anti-inflammatory and antioxidant properties on the development of lung injury and inflammation in rats insufflated with cytokines found in lung lavages of ARDS patients. ⋯ Ergothioneine should be considered for additional testing as a potential therapy for treating and preventing ARDS.