Preventive medicine
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Preventive medicine · Aug 2023
Yield and cost of government-organized colorectal cancer screening in young high-risk population in Northeast China.
Guidelines for colorectal cancer (CRC) screening recommend screening at age 40 for high-risk population in China. However, the yield and cost of CRC screening in younger population are lacking. This analysis aimed to evaluate the yield and cost of CRC screening in high-risk 40- to 54-year-olds. ⋯ Among the male screening population, NNS and cost to detect one advanced lesion in participants aged 45-49 years were similar to that aged 50-54 years, saving approximately half endoscopic resources and financial expenses compared with screening that aged 40-44 years. From the perspective of screening results and costs, it might be beneficial to delay the starting age of screening by gender. This study may provide reference for optimizing CRC screening strategies.
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Preventive medicine · Aug 2023
Factors associated with breast cancer screening services use among women in the United States: An application of the Andersen's behavioral model of health services use.
This study applied Andersen's Behavioral Model of Health Services Use to examine predisposing, enabling, and need factors associated with adherence to the United States Preventive Services Task Force (USPSTF) guidelines for breast cancer screening (BCS). Multivariable logistic regression was used to determine factors of BCS services utilization among 5484 women aged 50-74 from the 2019 National Health Interview Survey. Predisposing factors significantly associated with use of BCS services were: being a Black (odds-ratios [OR]:1.49; 95% confidence interval [CI]:1.14-1.95) or a Hispanic woman (OR:2.25; CI:1.62-3.12); being married/partnered (OR:1.32, CI:1.12-1.55); having more than a bachelor's degree (OR: 1.62; CI:1.14-2.30); and living in rural areas (OR:0.72; CI:0.59-0.92). ⋯ Disparities in BCS services utilization by Black and Hispanic women have been reduced. Disparities still exist for uninsured and financially restrained women living in rural areas. Addressing disparities in BCS uptake and improving adherence to USPSTF guidelines may require revamping policies that address disparities in enabling resources, such as health insurance, income, and health care access.
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Preventive medicine · Aug 2023
Analysis of metabolic syndrome and cognitive functional analysis in schizophrenic patients based on psychological intervention.
In this paper, we explore the characteristics of cognitive dysfunction in patients with schizophrenia complicated with metabolic syndrome (MS), and to explore the effects of psychological intervention on MS and cognitive function changes in patients with schizophrenia, and to provide theoretical basis for early intervention of MS. 159 patients with schizophrenia were retrospectively analyzed and divided into 2 groups according to whether they were accompanied by MS. (41 cases), the second group was not MS. (118 cases). Results shows PANSS total score as (53.72 ± 5.03), positive symptom score (12.39 ± 2.68), negative symptom score (14.94 ± 3.27), general pathological score (26.27 ± 3.63). ⋯ Increasing psychological intervention can effectively improve the therapeutic effect and cognitive function of schizophrenia patients. Early identification and intervention of MS in the clinical treatment of schizophrenia is particularly important.
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Preventive medicine · Aug 2023
OIP5-AS1 accelerates apoptosis of hippocampal neurons in cell models of epilepsy by modulating MiR-128-3p/BAX axis.
As a chronic neurological disorder, epilepsy (EP) is characterized with recurrent and unexplained epileptic seizures. Mounting evidence demonstrated that long non-coding RNAs (lncRNAs) are associated with EP. This paper intended to study the role and mechanisms of OIP5 antisense RNA 1 (OIP5-AS1) in EP. ⋯ OIP5-AS1 interacts with miR-128-3p to overexpress BCL2-Associated X (BAX), thereby modulating cell apoptosis in EP cell models. OIP5-AS1 accelerates apoptosis of hippocampal neurons in cell models of EP by modulating miR-128-3p/BAX axis. Investigating OIP5-AS1/miR-128-3p/BAX regulatory axis can contribute to deepening the understanding of EP.
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Preventive medicine · Aug 2023
Design and localization algorithm of flap guide plate for jaw defect based on digital 3D printing.
The anterolateral thigh flap is often used to repair the wound tissue defect. Because it is difficult to carry out the perforating vessels before and after the operation, it is considered to use digital design combined with 3D printing technology to prepare the digital three-dimensional guide plate, and at the same time, the guide plate positioning algorithm is designed according to the error caused by the different placement of the guide plate at the site to be transplanted. ⋯ In the experiment, the soft tissue of the patients with jaw defects can be well repaired based on the guide plate. The positioning algorithm locates the flap graft under the condition of less environmental parameters, and obtains the corresponding diameter parameters.