Anticancer research
-
Anticancer research · Sep 2003
Comparative Study Clinical TrialComparison of FDG-PET and technetium-99m MIBI SPECT to detect metastatic cervical lymph nodes in well-differentiated thyroid carcinoma with elevated serum HTG but negative I-131 whole body scan.
The aim of this study was to evaluate the usefulness of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) single photon emission computed tomography (SPECT) in detecting metastatic cervical lymph nodes (LN) in well-differentiated thyroid carcinoma (DTC) after total thyroidectomy and radioiodine-131 (I-131) treatments in patients with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS). Fifteen DTC patients underwent nearly total thyroidectomy and I-131 treatments with cervical LN metastases were included in this study. ⋯ FDG-PET could detect all of the 15 (100%) patients with metastatic cervical LN, but Tc-99m MIBI SPECT revealed lesions in only 9 out of 15 (60%) patients (p value < 0.05). This study demonstrated that FDG-PET is more sensitive than Tc-99m MIBI SPECT in detecting metastatic cervical LN in DTC with elevated serum hTg levels but negative I-131 WBS.
-
Anticancer research · Sep 2003
Effects of UFT on thymidylate synthase and dihydropyrimidine dehydrogenase activities in lung cancer.
We measured thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase (DPD) activity and TS inhibition rate (TSIR) in tumor tissue and lymph node metastasis, considered predictors of response to DIFs, in patients with lung cancer. ⋯ After preoperative treatment with UFT, TS and DPD activities are significantly higher in lung tumor tissue than in normal lung tissue in patients with NSCLC.