Anticancer research
-
Anticancer research · Oct 2013
Survival in patients with metastatic spinal cord compression from prostate cancer is associated with the number of extra-spinal organs involved.
To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer. ⋯ The number of extra-spinal organs involved by metastases predicts survival in patients with MSCC from prostate cancer.
-
Some retrospective clinical studies have shown there to be an an association between the anaesthetic technique employed during breast cancer surgery and recurrence or metastases. Little is known about the direct effects of volatile anaesthetics on cancer cells. In the present study we investigated the effects of sevoflurane on estrogen receptor-positive (ER(+)) and estrogen receptor-negative (ER(-)) breast cancer cell functions that may contribute to metastatic potential. ⋯ In this in vitro model of breast cancer cell function, sevoflurane increased proliferation, migration and invasion in ER-positive MCF7 cells and increased proliferation, and migration but not invasion in ER-negative cells. However, the observed effect size was small and not dose-dependent.