Anticancer research
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Anticancer research · Jan 2014
Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B.
To characterize neurotoxicity induced by oxaliplatin, bortezomib, and epothilone-B as well as protection against their neurotoxicity using an in vitro model. ⋯ Oxaliplatin, bortezomib, and epothilone-B are neurotoxic in the PC12 model. Amifostine has a neuroprotective effect only against oxaliplatin-induced neurotoxicity, suggesting that these compounds have different mechanisms of neurotoxicity.