Current eye research
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The effects of pirfenidone were investigated on cultured human pterygium fibroblasts (HPFs). ⋯ These findings demonstrate that pirfenidone inhibits the proliferation, migration and procollagen secretion of HPFs at nontoxic concentrations by decreasing TGF-β expression. Thus, pirfenidone may be considered as a safe adjuvant for pterygium surgery to prevent recurrence.