Nuclear medicine communications
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Observational Study
Clinical evaluation of a block sequential regularized expectation maximization reconstruction algorithm in 18F-FDG PET/CT studies.
To investigate the clinical performance of a block sequential regularized expectation maximization (BSREM) penalized likelihood reconstruction algorithm in oncologic PET/computed tomography (CT) studies. ⋯ The BSREM reconstruction algorithm showed a relevant improvement compared with OSEM reconstruction in PET/CT studies in all evaluated categories. BSREM might be used in clinical routine in conjunction with TOF to achieve better/higher image quality and lesion detectability or in PET/CT-systems without TOF-capability for enhancement of overall image quality as well.
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Lu-DKFZ-PSMA-617, a urea-based compound, binds to the extracellular domain of prostate-specific membrane antigen, thus providing an effective target for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Before its therapeutic use, it is necessary that the radiation dosimetry of this radiopharmaceutical be studied to determine the safe activity that can be administered in patients to prevent haematological, renal and liver toxicity. The present study thus aimed to assess the pharmacokinetics and dosimetry of Lu-DKFZ-PSMA-617 in CRPC patients. ⋯ Lu-DKFZ-PSMA-617 therapy is a safe option in the treatment of mCRPC patients.