Klinische Pädiatrie
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Klinische Pädiatrie · Mar 2005
Case ReportsSevere valproic acid intoxication is associated with atrial tachycardia: secondary detoxication by hemoperfusion.
Valproic acid is an anticonvulsant drug which is associated with serious toxicity including fatal outcome in case of severe intoxication. Secondary detoxication by hemodialysis or hemoperfusion has been employed successfully in valproic acid intoxication. Cardiac arrhythmias have only been described rarely in valproic acid intoxication in humans. ⋯ The patient was successfully treated with hemoperfusion and intensive supportive care without implementation of a specific antiarrhythmic therapy. We conclude that patients with severe valproic acid intoxication may benefit from secondary detoxication. In addition to generally known symptoms valproic acid intoxication may also be associated with cardiac arrhythmias.
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Klinische Pädiatrie · Mar 2005
[Are there predictors for proliferative retinopathy of prematurity and is supplemental oxygen a useful conservative treatment option?].
Especially very immature preterm babies develop retinopathy of prematurity (ROP). This study aims at analysing risk factors for proliferative ROP and realizing the efficiency of supplemental oxygen therapy. ⋯ Especially measures against long duration of intubation could help to prevent high grade ROP. The supplemental oxygen therapy may have a positive effect on course.