Klinische Pädiatrie
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Recently, germline mutations of DICER1 have been identified in patients with rare neoplasms suggesting the existence of a newly discovered cancer prone syndrome. Initially, DICER1 mutations were identified in patients with familial pleuropulmonary blastoma. ⋯ The entire tumor spectrum and the respective tumor risks are unknown. We are in the process of launching a natural history study aimed at identifying more information on this new cancer syndrome.
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Klinische Pädiatrie · May 2013
Biography Historical Article[Research in pediatric hematology [Germany, 1970-2000]].
Professor Riehm was not only an excellent pediatric oncologist, but also an excellent hematologist. He was a mentor also for young scientists who were interested in hematological research as his/her main focus. ⋯ The sense of the top research directions of the time distinguishes him not only as a pioneer of the leukaemia therapy studies, but also as a pioneer in hematology. He created the environment in which research could blossom.