Journal of pediatric gastroenterology and nutrition
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J. Pediatr. Gastroenterol. Nutr. · Mar 2014
Multicenter Study Clinical TrialLubiprostone for the treatment of functional constipation in children.
Pediatric functional constipation is common; effective, easily administered treatment options are limited. Lubiprostone is an oral chloride channel protein-2 activator that stimulates gastrointestinal fluid secretion, softens stools, and facilitates bowel movements (BMs). We evaluated the safety and effectiveness of lubiprostone in children and adolescents with functional constipation. ⋯ Lubiprostone was efficacious and well tolerated in children and adolescents with functional constipation.
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J. Pediatr. Gastroenterol. Nutr. · Mar 2014
Randomized Controlled TrialDietary fiber mixture in pediatric patients with controlled chronic constipation.
The aim of the study was to test the clinical efficacy and effect on colonic transit time (CTT) of a dietary fiber mixture given to children with controlled chronic constipation (CC) after the withdrawal of stool softeners and enemas. ⋯ The fiber mixture did not prevent the suspension of stool softeners or lead to reduced CTT; however, the mixture promoted an increased frequency of defecation and an improvement in the stool consistency.