Journal of pediatric gastroenterology and nutrition
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J. Pediatr. Gastroenterol. Nutr. · Mar 2014
Multicenter Study Clinical TrialLubiprostone for the treatment of functional constipation in children.
Pediatric functional constipation is common; effective, easily administered treatment options are limited. Lubiprostone is an oral chloride channel protein-2 activator that stimulates gastrointestinal fluid secretion, softens stools, and facilitates bowel movements (BMs). We evaluated the safety and effectiveness of lubiprostone in children and adolescents with functional constipation. ⋯ Lubiprostone was efficacious and well tolerated in children and adolescents with functional constipation.