Archives of gerontology and geriatrics
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Arch Gerontol Geriatr · Nov 2017
Reliability and validity of the Tilburg Frailty Indicator (TFI) among Chinese community-dwelling older people.
To translate the Tilburg Frailty Indicator (TFI) into Chinese and assess its reliability and validity. ⋯ The Chinese TFI has good validity and reliability as an integral instrument to measure frailty of older people living in the community in China.
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Arch Gerontol Geriatr · Nov 2017
Sleep disturbances and risk of falls in an old Chinese population-Rugao Longevity and Ageing Study.
To explore the relationship between sleep disturbances and falls in an elderly Chinese population. ⋯ Poor sleep quality and several subcomponent sleep symptoms were consistently associated with increased risk of falls ≥1 time and ≥2 times in Chinese elderly. The identification of sleep disturbances may help identify high-risk Chinese elders who may benefit from fall prevention education.
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Arch Gerontol Geriatr · Nov 2017
Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats.
Post operational cognitive dysfunction (POCD) occurs in patients after anesthesia and surgery. Abnormal histone acetylation and neuroinflammation are key factors in the pathogenesis of cognitive impairment. Apigenin not only has an anti-inflammatory activity but also modifies histone acetylation. We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling. ⋯ Memory impairment induced by isoflurane exposure is associated with dysregulated histone acetylation in the hippocampus, which affects BDNF expression and hence BDNF downstream signaling pathway. Apigenin recovers cognitive function by restoring histone acetylation and suppressing neuroinflammation.