IEEE transactions on medical imaging
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IEEE Trans Med Imaging · Sep 2008
Fast joint reconstruction of dynamic R2* and field maps in functional MRI.
Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) is conventionally done by reconstructing T(2)(*)-weighted images. However, since the images are unitless they are nonquantifiable in terms of important physiological parameters. An alternative approach is to reconstruct R(2)(*) maps which are quantifiable and have comparable BOLD contrast as T(2)(*)-weighted images. ⋯ To accelerate the algorithm we linearize the MR signal model, enabling the use of fast regularized iterative reconstruction methods. The regularizer was designed to account for the different resolution properties of both R(2)(*) and field maps and provide uniform spatial resolution. For fMRI data with the same temporal frame rate as data collected for T(2)(*)-weighted imaging the resulting R(2)(*) maps performed comparably to T(2)(*)-weighted images in activation detection while also correcting for spatially global and local temporal changes in off-resonance.