Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
-
Intramedullary spinal cord abscesses are rare and can be potential harmful lesions that cause a variety of neurologic problems. It is a treatable cause of paraparesis; however, diagnosis is not often straightforward due to the indolent course and rarity of the disease. ⋯ Strong clinical suspicion, in addition to prompt surgical drainage with proper antibiotic therapy, seems crucial in prevention of permanent neurological disability.
-
Clinical Trial
Patient-controlled analgesia with fentanil and midazolam in children with postoperative neurosurgical pain.
Pain is the most common discomfort experienced by children undergoing major operations. It is most often not adequately treated because of inexperience and unfounded fears related to the use of opioid drugs. In adults, patient-controlled analgesia (PCA) is widely administered, while in children, its use with opioid drugs is still under evaluation for safety and efficacy. ⋯ PCA with fentanil plus continuous infusion of midazolam is a safe and efficacious method for analgesia in children with moderate to severe postoperative neurosurgical pain. The association of midazolam to fentanil also contributes to control anxiety and stress in this subset of patients and does not show any important side effects.
-
Puncture of the ventricular system as one of the most frequently performed operative procedures in neurosurgery is usually done in a freehand way without guiding devices. The objective of this study is to examine whether ultrasonic guidance is able to heighten the accuracy of ventricular tapping. ⋯ The presented ultrasound method was not able to heighten the access rate of ventricular tapping, but it improved correct positioning of the catheter tip inside the frontal horn of the ventricular system significantly.
-
Case Reports
Ethylenevinylalcohol copolymer (Onyx-18) used in endovascular treatment of vein of Galen malformation.
Vein of Galen malformations (VGM) are rare congenital arteriovenous fistulas that usually present with heart failure in the neonate. Endovascular treatment options in the past have utilized coils, balloons, and acrylics. ⋯ We present, for the first time in the literature, a case of an infant with VGM treated initially with staged coil embolizations followed 1 year later by the transarterial and transvenous catheter based injection of Onyx-18 (ethylenevinylalcohol copolymer) in a single treatment session. The fistula was eliminated, and the infant's cardiopulmonary symptoms were improved.
-
Melatonin, the secretory product of the pineal gland, has potent antioxidant properties. The aim of this study was to compare the effects of low-dose (10 mg/kg) vs high-dose (50 mg/kg) melatonin on early lipid peroxidation levels and ultrastructural changes in experimental blunt sciatic nerve injury (SNI). We believe this to be the first study to assess the dose-dependent neuroprotective effects of melatonin after a blunt peripheral nerve injury. ⋯ Our results suggest that melatonin, especially at a dose of 50 mg/kg, has a potent neuroprotective effect and can preserve peripheral neural fibers from lipid peroxidative damage after blunt trauma. With further investigations, we hope that these data may prove useful to clinicians who treat patients with nerve injuries.