Bone
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In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. Therefore, we assessed the current trends in the number and incidence of low-trauma distal humeral fractures in Finnish women 60 years of age or older by taking into account all women who were admitted to Finnish hospitals for primary treatment of such fracture in 1970-2007. ⋯ Also, in all age groups (60-69, 70-79, and 80-) the trend of age-specific incidence was increasing from 1970 till the end of 1990s, and decreasing thereafter. In conclusion, the clear rise in the rate of low-trauma distal humeral fractures in Finnish women 60 years of age and older from 1970 till late 1990s has been followed by stabilized or even decreased fracture rates. The precise reasons for this secular change are unknown, but a cohort effect towards improved functionality among older women and actions and interventions in preventing falls and minimizing fall severity cannot be ruled out.
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Fracture healing is impaired in osteoporotic bone. Low-magnitude high-frequency vibration (LMHFV) has recently been proven to be osteogenic in osteoporotic intact bone. Our previous study found that LMHFV significantly enhanced fracture healing in adult rats. ⋯ Callus formation, mineralization and remodeling were enhanced by 25-30%, with a 70% increase in energy to failure than OVX-C. However, Sham-V was found to have lesser fracture healing enhancement, with significant increase in callus area only on week 2 and 3 than Sham-C, suggesting non-OVX aged bones were less sensitive to mechanical loading. The findings of this study provide a good basis to suggest that proceeding to clinical trials is the next step to evaluate the efficacy of LMHFV on osteoporotic fracture healing.