Computer methods and programs in biomedicine
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Comput Methods Programs Biomed · Aug 2008
Model-based identification of PEEP titrations during different volemic levels.
A cardiovascular system (CVS) model has previously been validated in simulated cardiac and circulatory disease states. It has also been shown to accurately capture all main hemodynamic trends in a porcine model of pulmonary embolism. In this research, a slightly extended CVS model and parameter identification process are presented and validated in a porcine experiment of positive end-expiratory pressure (PEEP) titrations at different volemic levels. ⋯ Errors for the identified model are within 5% when re-simulated and compared to clinical data. All identified parameter trends match clinically expected changes. This work represents another clinical validation of the underlying fundamental CVS model, and the methods and approach of using them for cardiovascular diagnosis in critical care.
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Comput Methods Programs Biomed · Aug 2008
MARVIN: a medical research application framework based on open source software.
This paper describes the open source framework MARVIN for rapid application development in the field of biomedical and clinical research. MARVIN applications consist of modules that can be plugged together in order to provide the functionality required for a specific experimental scenario. ⋯ Furthermore, it implements an advanced visualization system and interfaces to a wide range of 3D tracking hardware. Since it uses only highly portable libraries, MARVIN applications run on Unix/Linux, Mac OS X and Microsoft Windows.