Computer methods and programs in biomedicine
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Comput Methods Programs Biomed · Oct 2015
Implementation of a two-group likelihood time-to-event continual reassessment method using SAS.
Dose finding trials using model-based methods have the ability to handle the increasingly complex landscape being seen in clinical trials. Issues such as patient heterogeneity in trial populations are important to address in the designing of a trial in addition to the inclusion/exclusion criteria. Designs accommodating patient heterogeneity have been described using the continual reassessment method (CRM) and time-to-event CRM (TITE-CRM), yet, the implementation of these trials in practice have been limited. These methods and other model-based methods generally need statisticians to help design and conduct these trials. However, the statistical programs which facilitate the use of these methods, currently available focus on estimation in the one-sample case. ⋯ This program provides researchers with a valuable tool for designing dose-finding studies to account for the presence of patient heterogeneity and conduct a trial using a hypothetical example.