Computer methods and programs in biomedicine
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Comput Methods Programs Biomed · Aug 2020
The effect of non-fusion dynamic stabilization on biomechanical responses of the implanted lumbar spine during whole-body vibration.
Non-fusion dynamic stabilization surgery is increasingly popular for treating degenerative lumbar disc disease. However, changes in spine biomechanics after application of posterior dynamic fixation devices during whole-body vibration (WBV) remain unclear. The study aimed to examine the effects of non-fusion dynamic stabilization on biomechanical responses of the implanted lumbar spine to vertical WBV. ⋯ This study may be helpful to understand variations in vibration characteristics of the lumbar spine after application of non-fusion dynamic stabilization system.
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Comput Methods Programs Biomed · Aug 2020
The effect of cardiac output on the pharmacokinetics and pharmacodynamics of propofol during closed-loop induction of anesthesia.
Intraoperative hemodynamic stability is essential to safety and post-operative well-being of patients and should be optimized in closed-loop control of anesthesia. Cardiovascular changes inducing variations in pharmacokinetics may require dose modification. Rigorous investigational tools can strengthen current knowledge of the anesthesiologists and support clinical practice. We quantify the cardiovascular response of high-risk patients to closed-loop anesthesia and propose a new application of physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) simulations to examine the effect of hemodynamic changes on the depth of hypnosis (DoH). ⋯ Significant CO drops produce increased predicted plasma concentrations corresponding to deeper anesthesia, which is potentially dangerous for elderly patients. PBPK-PD model simulations allow studying and quantifying these effects to improve clinical practice.