The Clinical journal of pain
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Previous research suggests that children with autism spectrum disorders (ASD) are at a higher risk for painful experiences, but there is limited research examining pain in children with ASD. ⋯ This is the first study to successfully obtain self-report of pain from youth with ASD. Implications for the understanding of pain and pain assessment in high-functioning youth with ASD are discussed.
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Comparative Study
Comparison of a novel direct measure of rapid pain intensity change to traditional serial 100 mm VAS measurement of pain intensity.
Key diagnostic decisions often turn on measurement of change in pain intensity after diagnostic anesthetic blocks. This study aimed to introduce a new direct measure pain intensity change and compare it with percent change as calculated from the traditional preprocedure and postprocedure pain visual analog scales. ⋯ The 2 methods are not interchangeable. The new method measures the pain intensity change dimension directly, whereas the traditional method estimates change indirectly by calculation. Face validity is better served by adopting the new method for decisions regarding whether a patient is a "responder" or "nonresponder" to diagnostic blocks. The traditional method should be retained for estimation of pain intensity preprocedure and the duration of pain relief postprocedure.
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To identify predictive factors for the occurrence of postherpetic neuralgia (PHN). ⋯ Our study indicates that advanced age and deep pain at the initial visit are significant predictors for PHN. Our results are considered likely to contribute to the establishment of evidence-based medicine in the optimal treatment of PHN.
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Randomized Controlled Trial Clinical Trial
Low back pain subgroups using fear-avoidance model measures: results of a cluster analysis.
The purpose of this secondary analysis was to test the hypothesis that an empirically derived psychological subgrouping scheme based on multiple Fear-Avoidance Model (FAM) constructs would provide additional capabilities for clinical outcomes in comparison with a single FAM construct. ⋯ These data suggest that subgrouping based on multiple FAM measures may provide additional information on clinical outcomes in comparison with determining subgroup status by FABQ-PA alone. Subgrouping methods for patients with low back pain should include multiple psychological factors to further explore if patients can be matched with appropriate interventions.
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Randomized Controlled Trial Clinical Trial
Interaction of fentanyl and buprenorphine in an experimental model of pain and central sensitization in human volunteers.
: There is controversy about combining opioids with different receptor affinities. We assessed the analgesic and antihyperalgesic effects of the μ-agonist fentanyl and the partial μ-agonist/κ-antagonist buprenorphine in a human pain model, when given alone or in combination. ⋯ : For the doses administered in this study, buprenorphine and fentanyl showed an additive interaction.