The Journal of international medical research
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Randomized Controlled Trial
Optimal dose of dexmedetomidine for attenuating cardiovascular response during emergence in patients undergoing total laparoscopic hysterectomy.
To investigate the optimal dose of dexmedetomidine for attenuating the haemodynamic response during emergence from anaesthesia. ⋯ Intravenous infusion of 0.5 µg/kg dexmedetomidine 30 min before the end of surgery attenuated the haemodynamic responses during emergence without prolonging the extubation time. Dexmedetomidine doses higher than 0.5 µg/kg did not exert additional positive effects on cardiovascular responses, but did significantly prolong the extubation time.
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Randomized Controlled Trial
The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study.
The efficacy and side-effects of nefopam were prospectively compared with those of fentanyl for patient-controlled analgesia (PCA) following cardiac surgery. ⋯ PCA with nefopam alone provides suitable postoperative analgesia after cardiac surgery.
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Randomized Controlled Trial
Influence of levosimendan on organ dysfunction in patients with severely reduced left ventricular function undergoing cardiac surgery.
Levosimendan is an inotropic drug with organ-protective properties due to its activation of mitochondrial K(ATP) channels. This prospective, randomized, double-blind, placebo-controlled study investigated whether administration of levosimendan prior to cardiopulmonary bypass could reduce organ dysfunction and influence subsequent secondary endpoints. ⋯ These preliminary results show that timely perioperative levosimendan treatment is feasible, has a favourable safety profile safe and may help to prevent low cardiac output syndrome. However, organ function was not preserved. Further studies, using larger sample sizes, are required.
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Randomized Controlled Trial
Influence of goal-directed therapy with balanced crystalloid-colloid or unbalanced crystalloid solution on base excess.
To investigate changes in standard base excess (SBE) when administering two different infusion regimens for elective hip replacement within a goal-directed haemodynamic algorithm. ⋯ SBE decreased in the unbalanced group without influence on fluid requirements and haemodynamic stability.
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Randomized Controlled Trial Clinical Trial
Efficacy of intraperitoneal and intravenous lidocaine on pain relief after laparoscopic cholecystectomy.
This randomized, double-blind, placebo-controlled trial evaluated intraperitoneal (IP) lidocaine administration and intravenous (IV) lidocaine infusion for postoperative pain control after laparoscopic cholecystectomy (LC). ⋯ The IP administration of lidocaine and IV lidocaine infusion significantly reduced postoperative pain and opioid consumption in LC patients, compared with control infusions. For convenience, IV lidocaine could be used for pain reduction following LC; IP administration places additional burden on the surgeon.