Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
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Comparative Study
Biochemical response after 3-d conformal radiotherapy of localized prostate cancer to a total dose of 66 gy 4-year results.
Since the introduction of 3-D conformal radiotherapy (CRT) doses of /= 70 Gy should be considered. As a consequence of our earlier analysis a prospective multicenter treatment optimization protocol has been initiated in 1999. The protocol includes a risk-adapted dose increase from 70 Gy in low-risk patients to 74 Gy in high-risk patients including short-term androgen ablation.
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Patients with metastatic spinal cord compression are often presented for emergency radiotherapy. The optimum radiotherapeutic regimen is still debated, studies comparing different radiation schedules on therapeutic outcome are scarce. This analysis compares the effect of two schedules on motor function considering three relevant prognostic factors (type of primary tumor, pre-treatment ambulatory status, time of developing motor deficits before radiotherapy). ⋯ The two radiation schedules were comparable for functional outcome. The less time consuming schedule (30 Gy/10 fractions) can be recommended in metastatic spinal cord compression, as life expectancy is markedly reduced in the majority of these patients.