Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
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In elderly patients, patients with multiple morbidities, and patients with a reduced general condition, the standard treatment of inoperable non-small-cell lung cancer (NSCLC) consists of either chemotherapy or radiation therapy alone and is associated with an extremely poor prognosis. We therefore investigated the feasibility, toxicity, and efficacy of radiotherapy with concurrent chemotherapy using vinorelbine plus cisplatin or carboplatin in NSCLC patients at risk for treatment complications. ⋯ Conventionally fractionated radiochemotherapy with vinorelbine plus a platinum derivative is feasible in patients with NSCLC and increased risk of treatment complications. Compared to patient populations described in the literature, the survival rates achieved by concurrent radiochemotherapy appear to be better than those achieved with radiotherapy alone.
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Comparative Study
Effects of radiation treatment planning and patient fixation on the results of postoperative radiotherapy of childhood medulloblastoma.
To assess the prognostic factors and the benefit of introducing head fixation and CT-assisted radiation treatment planning following postoperative radiotherapy in 83 children with medulloblastoma. ⋯ Metastatic disease appears to be correlated with a worse prognosis in this analysis. Individual radiation treatment planning and head fixation have a positive impact on survival. For postoperative radiotherapy of the posterior fossa, the application of head fixation and individual CT-based radiation treatment planning is considered indispensable in each case.