Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
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Review Comparative Study
Dose escalated external beam radiotherapy versus neoadjuvant androgen deprivation therapy and conventional dose external beam radiotherapy for clinically localized prostate cancer: do we need both?
Several randomized trials have demonstrated that men with localized prostate cancer benefit from the use of short-term neoadjuvant androgen deprivation therapy (NADT) in combination with external beam radiotherapy (EBRT), while other trials have shown improved outcomes with higher doses of radiation. This review compares both approaches and the rationale for using both. ⋯ The quality of the evidence supporting the use of NADT in combination with EBRT for clinically important endpoints is stronger than the data supporting dose escalation. Cure rates appear to be unacceptably low for both approaches such that higher doses of EBRT combined with NADT and whole pelvic radiotherapy may be indicated for optimal outcomes.