Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
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Review Comparative Study
Erythropoiesis-stimulating agents: favorable safety profile when used as indicated.
Several studies with erythropoiesis-stimulating agents (ESAs) have raised a number of safety issues. Therefore, a discussion of available data in light of the current EORTC guidelines 2006 on the use of ESAs in anemic patients is warranted. ⋯ When used as indicated, ESAs are valuable and safe drugs for the treatment of anemia and do not negatively affect patient survival. In particular, the data situation confirms the importance and correctness of the EORTC guidelines 2006 and their recently updated version. It is therefore recommended that these guidelines continue to be strictly followed in the treatment of chemotherapy-induced anemia.
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Comparative Study
[Long-term results following multidisciplinary treatment of localized Ewing's sarcoma in children and adolescents].
To identify results and prognostic factors on long-term survival and local control following treatment of localized Ewing's sarcoma. ⋯ Radiotherapy with and without surgery of Ewing's sarcoma is a highly effective local treatment option. It seems preferable to mutilating surgery.
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Clinical Trial
The use of molecular imaging to evaluate radiation fields in the adjuvant setting of breast cancer: a feasibility study.
To evaluate standard radiation fields in locally advanced breast cancer using the information of a preoperative FDG-PET showing lymph node involvement. ⋯ Standard radiation portals in postoperative radiation therapy in breast cancer with lymph node involvement do not automatically result in an adequate dose delivery to the region of highest biological activity. With these preliminary results in a small series it was found feasible to correct this without compromising the dose to the CTV or lungs for patients in whom a preoperative FDG-PET shows nodal involvement.
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Comparative Study
Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases.
Whole-brain radiotherapy (WBRT) is the most common treatment for brain metastases. Most of these patients have a poor survival prognosis. Therefore, a short radiation program is preferred, if it provides a similar outcome as longer programs. This study compares 20 Gy in five fractions (treatment time: 1 week) to longer programs, with higher doses including 30 Gy in ten fractions (2 weeks) and 40 Gy in 20 fractions (4 weeks). ⋯ Short-course WBRT with 20 Gy in five fractions is preferable for most patients, because it is associated with similar survival as longer programs and is less time-consuming.
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Helical tomotherapy was introduced into clinical routine at the Department of Radiation Oncology, University Hospital of Heidelberg, Germany, in July 2006. This report is intended to describe the experience with the first 150 patients treated with helical tomotherapy. Patient selection, time effort, handling of daily image guidance with megavoltage (MV) CT, and quality of radiation plans shall be assessed. ⋯ Helical tomotherapy and daily image guidance with MV-CT could fast be introduced into daily clinical routine. This technique allows precise intensity-modulated radiotherapy (IMRT) in standard cases and offers new treatment options in a huge variety of difficult cases.