Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
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Multicenter Study Comparative Study
Is short-course radiotherapy with high doses per fraction the appropriate regimen for metastatic spinal cord compression in colorectal cancer patients?
Various radiotherapy (RT) schedules are used worldwide for metastatic spinal cord compression (MSCC). Every treatment session may cause discomfort to the mostly debilitated patients. A short overall treatment time appears beneficial, especially for MSCC patients with an extremely poor survival such as colorectal cancer patients. This study evaluates whether short-course RT (1 x 8 Gy given in 1 day, 5 x 4 Gy given in 1 week) is as effective as long-course RT (10 x 3 Gy given in 2 weeks, 15 x 2.5 Gy given in 3 weeks, 20 x 2 Gy given in 4 weeks) and whether higher doses per fraction (more cell kill) and shorter overall treatment time (less repopulation) can compensate for lower total doses. ⋯ No significant difference was observed between short-course and long-course RT with respect to functional outcome. In the clinical situation, short-course RT may be considered preferable, as it means less patient discomfort.
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Review Comparative Study
Fractionated stereotactic radiation therapy in the management of benign cavernous sinus meningiomas : long-term experience and review of the literature.
To analyze own long-term results with fractionated stereotactic radiotherapy (FSRT) in patients with benign meningiomas of the cavernous sinus and to review the literature on these rare lesions. ⋯ These data demonstrate that FSRT is an effective and safe treatment modality for local control of benign cavernous sinus meningiomas with a minimal risk of significant late toxicity.
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Review Comparative Study
Biologically effective dose in total-body irradiation and hematopoietic stem cell transplantation.
Total-body irradiation (TBI) is an important part of the conditioning regimen for hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The results after treatment with various TBI regimens were compared, and dose-effect relationships for the endpoints relapse incidence, disease-free survival, treatment-related mortality, and overall survival were derived. The aim was to define requirements for an optimal treatment schedule with respect to leukemic cell kill and late normal-tissue morbidity. ⋯ "More dose is better", provided that a TBI setting is used limiting the BEDs of lungs, kidneys, and eye lenses.
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Comparative Study
Clinicopathologic features of aggressive meningioma emphasizing the role of radiotherapy in treatment.
Although meningiomas are typically benign, they occasionally behave in an aggressive fashion and carry a less favorable prognosis. The aim of this study was to review the clinical, radiologic and histopathologic features of these aggressive variants as well as the outcome after multimodality therapy. ⋯ Considering the higher rate of recurrence in aggressive meningiomas even after radical surgical excision and the possibility that the recurrent tumor is more aggressive than the original one, surgery should be combined with postoperative fractionated radiotherapy to improve local tumor control. The peculiar focal expression patterns of anaplastic meningioma in MIB-1 might be a marker of such malignant development.
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Comparative Study
Transperineal permanent seed implantation of "low-risk" prostate cancer: 5-year-experiences in 118 patients.
To evaluate 5-year prostate-specific antigen (PSA) relapse-free survival of transperineal permanent seed implantation (TPSI) in 118 patients with "low-risk" prostate cancer, that means stage cT1c-T2a, Gleason Score < 7, and initial PSA value < 10 ng/ml. ⋯ In low-risk prostate cancer patients, TPSI with intraoperative ultrasound-based treatment planning and fluoroscopy leads to excellent local tumor control and PSA relapse-free survival.