Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
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Randomized Controlled Trial Comparative Study Clinical Trial
Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study.
To assess whether the topical use of steroids or 5-aminosalicylic acid (5-ASA) is superior to sucralfate in preventing acute rectal toxicity during three-dimensional conformal radiotherapy (3DCRT) to 76 Gy. ⋯ Topical mesalazine is contraindicated during radiotherapy. Hydrocortisone enema is not superior to sucralfate in preventing acute rectal toxicity.
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Extranodal non-Hodgkin's lymphoma are mostly localized in the gastrointestinal tract. A small number of these lymphoma arise from specialized lymphoid cells, the so-called mucosa-associated lymphoid tissue (MALT). We describe one case with a metachronous occurrence of a MALT-type lymphoma of the conjunctiva of both eyelids and supraglottic larynx. ⋯ Extranodal, primary low grade B-cell MALT-type lymphoma are rare. In the literature only few cases of each larynx- and conjunctival eyelid involvement described. The radiotherapy has been reported to achieve a long time of relapse-free interval. The present case demonstrates, that even the recurrence of an extranodal, primary low-grade B-cell MALT-type lymphoma responds well to local radiotherapy and can also have a long period of no evidence of disease.
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Tumor doses > 70 Gy are needed for local control in adenoid cystic carcinomas. These tumor doses cannot be delivered if the tolerance doses to neighboring organs at risk (OAR) are respected. This treatment planning study investigates the physical advantage of combined photon intensity-modulated radiation therapy (IMRT) plus carbon ion boost compared to photon IMRT alone. ⋯ The combination of photon IMRT with carbon ions improves the target coverage for the boost volume and offers better sparing of OAR close to the PTV2 (gross tumor volume) in comparison with photon IMRT alone. A clinical study has been initiated to evaluate whether these potential advantages translate into clinical benefit.
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Comparative Study
Reirradiation of locally recurrent nasopharyngeal carcinoma.
To study the efficacy of reirradiation as salvage treatment in patients with locally recurrent nasopharyngeal carcinoma. ⋯ Retreatment of nasopharyngeal carcinoma with radiotherapy (preferably a combined modality), can result in longterm local control and survival in a substantial proportion of patients, at the price of an acceptable morbidity.
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Comparative Study
Dosimetric assessment of the field abutment region in head and neck treatments using a multileaf collimator.
The use of conventional asymmetric collimators for junctioning of abutted fields can lead to significant dose inhomogeneity, due to jaw misalignment. However, recent technologic advances enable us to fabricate much finer leafpositioning accuracy. Consequently, it is anticipated that the use of multileaf collimator (MLC) will potentially improve dose homogeneity at the junction of abutted fields. In this work, we evaluated the dose inhomogeneities at the match-plane in monoisocentric three-field head and neck setups, using MLC for field abutment. ⋯ The use of MLCs for photon field junction matching is appropriate and represents an alternative approach to the problem of field matching using the asymmetric jaws in head and neck treatments.