Journal of critical care
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Journal of critical care · Apr 2021
Interactions between carbapenems and valproic acid among the patients in the intensive care units.
To evaluate risk factors for epileptic seizures or status epilepticus (SE) in patients concomitantly receiving valproic acid (VPA) and carbapenems. ⋯ Carbapenems decreased VPA serum concentration and increased the risk of epileptic seizures and SE, which led to increased length of ICU stay.
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Journal of critical care · Apr 2021
Randomized Controlled Trial Multicenter StudyEffect of non-sedation on physical function in survivors of critical illness - A substudy of the NONSEDA randomized trial.
Critical illness impairs physical function. The NONSEDA trial was a multicenter randomized trial, assessing non-sedation versus sedation during mechanical ventilation. The aim of this sub-study was to assess the effect of non-sedation on physical function. ⋯ Non-sedation did not lead to improved quality of life regarding physical function or better function in activities of everyday living. Non-sedated patients had a better physical recovery at ICU discharge.
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Journal of critical care · Apr 2021
ReviewFamily participation in physiotherapy-related tasks of critically ill patients: A mixed methods systematic review.
Providing an overview of studies on family participation in physiotherapy-related tasks of critically ill patients, addressing two research questions (RQ): 1) What are the perceptions of patients, relatives, and staff about family participation in physiotherapy-related tasks? and 2) What are the effects of interventions of family participation in physiotherapy-related tasks? ⋯ Positive attitudes were observed among patients, their relatives and staff towards family participation in physiotherapy-related tasks of critically ill patients. However, limited research has been done into the effect of interventions containing family participation in physiotherapy-related tasks.
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Journal of critical care · Apr 2021
ReviewMajor publications in the critical care pharmacotherapy literature: 2019.
To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019. ⋯ This clinical review and expert opinion provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2019.
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Journal of critical care · Apr 2021
Multicenter StudyIncreasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study.
To assess the association between serum ammonia level upon admission during the initial intensive care unit (ICU) stay and mortality. ⋯ Elevated serum ammonia level in critically ill patients upon admission was an early risk factor for higher ICU and in-hospital mortality.