Journal of critical care
-
Journal of critical care · Jun 1999
Randomized Controlled Trial Multicenter Study Clinical TrialIL-1ra administration does not improve cardiac function in patients with severe sepsis.
The purpose of this study was to investigate the effects of interleukin-1 receptor antagonist (IL-1ra) on myocardial function in septic patients. ⋯ IL-1ra administration has no effect on cardiac function in septic patients.
-
Journal of critical care · Sep 1998
Randomized Controlled Trial Multicenter Study Clinical TrialSurrogates' agreement with patients' resuscitation preferences: effect of age, relationship, and SUPPORT intervention. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment.
The purpose of this study was to evaluate an intervention to improve patient-surrogate agreement on end-of-life resuscitation preferences. ⋯ The SUPPORT intervention was not successful in increasing agreement between patients and surrogates. Because of the complex issues involved in end-of-life decision-making, a more aggressive intervention may be needed. Other findings suggest that improvements in communication are particularly needed when patients are older and when the surrogate is not a patient's immediate relative.
-
Journal of critical care · Dec 1995
Multicenter Study Comparative Study Clinical TrialThe influence of clinical study design on cost-effectiveness projections for the treatment of gram-negative sepsis with human anti-endotoxin antibody.
This study was performed to compare the effect of entry criteria, patient population, and study design on outcome and projected cost-effectiveness of human anti-endotoxin antibody (HA-1A). ⋯ Extrapolating cost-effectiveness from RCT-derived analyses to open-label usage may yield widely inaccurate projections because of only small differences in patient population and the drug administration protocol.