Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Editorial Comment
The role of clonidine and alpha 2-agonists for postoperative analgesia.
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Randomized Controlled Trial Clinical Trial
Neostigmine but not edrophonium prolongs the action of mivacurium.
To examine the influence of anticholinesterase drugs neostigmine and edrophonium (which have different effects on plasma cholinesterase activity) administered for antagonism of neuromuscular block on the duration of action of mivacurium (a neuromuscular blocking drug metabolised by plasma cholinesterase). ⋯ The duration of action of mivacurium is prolonged by previous administration of neostigmine and this is most likely to be due to inhibition of PCHE activity.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparative assessment of the anaesthetic and analgesic effects of intramuscular and epidural clonidine in humans.
The aim of the study was to assess and compare in analogous controlled experimental conditions, the anaesthetic sparing and analgesic effects of the same dose of clonidine administered by the intramuscular (im) and epidural (ep) routes. ⋯ Epidural and intramuscular clonidine decreased isoflurane requirements similarly, but only the epidural route provided postoperative analgesia, suggesting a spinal site for the analgesic action.
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Randomized Controlled Trial Clinical Trial
Terbutaline inhalation suppresses fentanyl-induced coughing.
To study the suppressive effect of inhalation of a selective beta 2-adrenergic bronchodilator terbutaline, and the effect of an intravenous anticholinergic, atropine, on fentanyl-induced coughing. ⋯ The inhalation of a selective beta 2-adrenergic bronchodilator, terbutaline, effectively inhibited fentanyl-induced cough, whereas atropine, an antimuscarinic vagolytic, had no efficacy. Our results suggest that bronchoconstriction may underlie the mechanism on fentanyl-induced cough.