Critical care medicine
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Critical care medicine · Feb 1995
Frequency and importance of barotrauma in 100 patients with acute lung injury.
To determine the occurrence rate of barotrauma in acute lung injury patients, whether barotrauma is an independent risk factor for mortality, and the role of barotrauma in the outcome of those patients who died. ⋯ Barotrauma occurred in only 13% of patients with acute lung injury. Barotrauma was an independent marker of mortality when adjusted for other predictors of mortality. However, barotrauma directly contributed to < 2% of all deaths. We hypothesize that barotrauma is an indication of severity of acute lung injury rather than a major cause of increased mortality.
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Critical care medicine · Feb 1995
Multicenter Study Comparative StudyComparative assessment of pediatric intensive care: a national multicenter study. Pediatric Intensive Care Assessment of Outcome (PICASSO) Study Group.
Comparative assessment of performance of pediatric intensive care. ⋯ Differences in mortality rates among pediatric ICUs were largely explained by differences in severity of illness. High efficiency rates combined with adequate effectiveness were found in several centers, indicating that admission and discharge decisions might be improved in less efficient centers.
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Critical care medicine · Feb 1995
Editorial CommentBarotrauma in acute lung injury: is it important?
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Critical care medicine · Feb 1995
Randomized Controlled Trial Comparative Study Clinical TrialComparison of propofol and midazolam for sedation in intensive care unit patients.
To evaluate the comparative safety and effectiveness of intravenous infusion of propofol or midazolam when used for 12 to 24 hrs of sedation and to evaluate the quality of sedation during stimulation. ⋯ Propofol was as safe and as efficacious as midazolam for continuous intravenous sedation. The quality of sedation was better in the propofol group.
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Critical care medicine · Feb 1995
L-arginine: nitric oxide pathway in endotoxemia and human septic shock.
To investigate the relationship between nitric oxide production, endotoxemia, and hemodynamic alterations in human septic shock. ⋯ This study demonstrated the activation of the L-arginine:nitric oxide pathway in human endotoxemic septic shock, suggesting that nitric oxide may be an important mediator of the hemodynamic disturbances in this pathophysiologic situation.