Alimentary pharmacology & therapeutics
-
Aliment. Pharmacol. Ther. · Feb 2007
Meta AnalysisMeta-analysis: ondansetron for vomiting in acute gastroenteritis in children.
Vomiting is a common sympton in children with gastroenteritis, but its treatment remains controversial. ⋯ Despite some clinical benefits, there is insufficient evidence to recommend the routine use of ondansetron for vomiting during acute gastroenteritis in children.
-
Aliment. Pharmacol. Ther. · Feb 2007
Meta AnalysisMeta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children.
Saccharomyces boulardii is a non-pathogenic probiotic yeast considered useful against enteropathogens. ⋯ There exists a moderate clinical benefit of S. boulardii therapy in otherwise healthy infants and children with acute gastroenteritis, mainly a shorter duration of diarrhoea. However, these results should be interpreted with caution due to methodological limitations of the included studies.
-
Aliment. Pharmacol. Ther. · Feb 2007
Randomized Controlled TrialNeurokinin-1 receptor antagonism in a human model of visceral hypersensitivity.
Substance P acting via the neurokinin-1 receptor is involved in the development of hyperalgesia, although studies using neurokinin-1 receptor antagonists (NK-1RA) in human somatic pain have been disappointing. ⋯ The lack of effect of NK-1RA on oesophageal pain threshold in our model does not support a role for Substance P in the development of acid-induced oesophageal allodynia.