Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Feb 2007
Randomized Controlled TrialNeurokinin-1 receptor antagonism in a human model of visceral hypersensitivity.
Substance P acting via the neurokinin-1 receptor is involved in the development of hyperalgesia, although studies using neurokinin-1 receptor antagonists (NK-1RA) in human somatic pain have been disappointing. ⋯ The lack of effect of NK-1RA on oesophageal pain threshold in our model does not support a role for Substance P in the development of acid-induced oesophageal allodynia.