Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Apr 2007
Randomized Controlled Trial Comparative StudyProspective randomized trial evaluating ketamine for advanced endoscopic procedures in difficult to sedate patients.
Adequate patient sedation is mandatory for advanced endoscopic procedures such as ERCP and EUS. ⋯ Ketamine is a useful adjunct to conscious sedation in patients who are difficult to sedate. Its use Results in better quality and depth of sedation with shorter recovery times than patients sedated using benzodiazepines and meperidine alone. Further prospective studies evaluating the effectiveness and safety of ketamine for endoscopic sedation are needed.
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Aliment. Pharmacol. Ther. · Mar 2007
Randomized Controlled Trial Multicenter StudyAn open-label study of chronic polyethylene glycol laxative use in chronic constipation.
Polyethylene glycol 3350 (MiraLAX, Braintree Laboratories Inc., Braintree, MA, USA) is approved for the short-term treatment of occasional constipation. ⋯ Polyethylene glycol laxative is safe and effective for treating constipation in adult and elderly patients for periods up to 12 months, with no evidence of tachyphylaxis.
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Aliment. Pharmacol. Ther. · Mar 2007
Meta AnalysisMeta-analysis: randomized controlled trials of clindamycin/aminoglycoside vs. beta-lactam monotherapy for the treatment of intra-abdominal infections.
To compare the effectiveness and safety of clindamycin/aminoglycoside with broad-spectrum beta-lactam monotherapy in patients with intra-abdominal infections by performing a meta-analysis of randomized controlled trials (RCTs). ⋯ The results of our meta-analysis suggest that beta-lactams are more effective in the treatment of intra-abdominal infections compared with clindamycin/aminoglycoside.
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Aliment. Pharmacol. Ther. · Feb 2007
Meta AnalysisMeta-analysis: ondansetron for vomiting in acute gastroenteritis in children.
Vomiting is a common sympton in children with gastroenteritis, but its treatment remains controversial. ⋯ Despite some clinical benefits, there is insufficient evidence to recommend the routine use of ondansetron for vomiting during acute gastroenteritis in children.
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Aliment. Pharmacol. Ther. · Feb 2007
Randomized Controlled TrialNeurokinin-1 receptor antagonism in a human model of visceral hypersensitivity.
Substance P acting via the neurokinin-1 receptor is involved in the development of hyperalgesia, although studies using neurokinin-1 receptor antagonists (NK-1RA) in human somatic pain have been disappointing. ⋯ The lack of effect of NK-1RA on oesophageal pain threshold in our model does not support a role for Substance P in the development of acid-induced oesophageal allodynia.