Hematology/oncology clinics of North America
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Hematol. Oncol. Clin. North Am. · Oct 1992
Review Multicenter Study Clinical TrialCurrent concepts in coronary thrombolysis.
It has become increasingly apparent that the success of coronary thrombolysis depends on a dynamic balance between fibrinolytic and procoagulant activity. The differential properties of specific plasminogen activators determine the rate at which clot lysis is induced, the extent to which procoagulant activity and platelet activation are increased, and the extent to which recurrent thrombosis is inhibited. ⋯ The recent development of a variety of new anticoagulants with different mechanisms of action may result in even more effective treatment strategies. Whether these newer agents will result in improved survival in patients treated with coronary thrombolysis without compromising safety will need to be established by clinical trials.