Hematology/oncology clinics of North America
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Hematol. Oncol. Clin. North Am. · Dec 2007
Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma.
In 1978, the term "monoclonal gammopathy of undetermined significance" (MGUS) was introduced. MGUS is defined as a serum monoclonal (M) protein less than 3.0 g/dL; less than 10% plasma cells in the bone marrow, if done; little or no M protein in the urine; and absence of lytic bone lesions, anemia, hypercalcemia or renal insufficiency. ⋯ Management of the disease is discussed along with its association with other disorders. Information on smoldering multiple myeloma is included.