Brain injury : [BI]
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Brain injury : [BI] · Jan 2017
Additive effects of sequential excitatory and inhibitory theta burst stimulation in improving cortical excitability following ischaemic stroke.
To study the effects of sequential excitatory and inhibitory theta burst stimulation (TBS) on cortical excitability in patients with subacute ischaemic stroke. ⋯ The results indicate that combining iTBSSH and cTBSIH can have additive effect in increasing cortical excitability in subacute ischaemic patients with stroke.
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Brain injury : [BI] · Jan 2017
Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.
To investigate the protective effect of hypothermia (HT) on brain injury in moderate traumatic brain injury (TBI) rat models and the potential mechanisms, especially the involvement of RIPK1 in apoptosis and necroptosis. ⋯ HT treatment significantly reduced RIPK-1 upregulation, which may inhibit necroptosis and apoptosis pathways after moderate TBI.
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Brain injury : [BI] · Jan 2016
Day-to-day variability of post-concussion-like symptoms reported over time by a non-concussed cohort.
To explore the change (trend) in post-concussion-like symptoms reported over time. ⋯ The data indicated that non-concussed participants exhibited considerable individual variability in the symptom scores reported over time. However, some participants showed a systematic decreasing trend in their symptom scores reported over the 7 days. Caution must be exercised in interpreting the serial symptom scores that are obtained following a concussion, given that this study was conducted in a non-concussed cohort.
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Brain injury : [BI] · Jan 2016
ReviewBrain injury biomarkers in the setting of cardiac surgery: Still a world to explore.
Brain injury is an important, potentially devastating, complication in cardiac surgery. A significant number of patients suffer perioperative complications involving the central nervous system. Clinical manifestations of brain injury are associated with significantly increased mortality, morbidity and health resource utilization. Serum biomarkers have been studied in cardiac surgery to measure the degree and incidence of brain injury and to improve patient management. ⋯ These biomarkers, independently of clinical and radiological findings, show global cerebral situation at the cellular level and the degree of brain dysfunction. However, up to date, there is no biomarker entirely suitable for the detection of brain injury after cardiac surgery.
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Brain injury : [BI] · Jan 2016
Preliminary findings on biomarker levels from extracerebral sources in patients undergoing trauma surgery: Potential implications for TBI outcome studies.
Despite several experimental studies on the role of S100B and NSE in fractures, no studies on the influence of surgery on the biomarker serum levels have been performed yet. ⋯ This study demonstrates significant alterations of the biomarker S100B serum levels in patients undergoing surgery. Higher S100B serum levels were found within 24 hours and might be related to the acute fracture. The NSE serum levels were unchanged and this biomarker may offer the probability to serve as a future outcome predictor in studies with patients with traumatic brain injury and additional extracerebral injuries.