British journal of neurosurgery
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The descriptions of two techniques allowing for CT target determination in functional neurosurgery are presented, the first for thalamic and peri-thalamic explorations in the treatment of dyskinesiae and chronic pain, the second for the implantation of multiple hemispheric depth electrodes in the assessment of chronic drug-resistant epilepsy.
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A cell line, 497-P(1), derived from the VM spontaneous murine astrocytoma has been used to develop an in vitro in vivo model of human glioma. This paper describes the growth characteristics of tumours produced after intracerebral or subcutaneous inoculation of 497-P(1) cells into syngeneic VM mice. The results show that cell line 497-P(1) provides the basis for a reproducible animal model of glioma which fulfils many of the criteria required for experimental therapy studies.
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Percutaneous retrogasserian glycerol rhizotomy has shown encouraging results in the treatment of trigeminal neuralgia. An experimental study was undertaken using a rat sciatic nerve model to elucidate the mechanism of action of anhydrous glycerol and to study the acute changes which develop within one week. Extraneural glycerol was applied in 20 adult Wistar rats. ⋯ The sciatic nerve of the opposite limb in the same animals was used as a control. The nerve were examined with light and electron microscopy including a morphometric study to assess the type of fibres affected. The specific pattern of involvement of larger and medium sized myelinated fibres with relative preservation of unmyelinated fibres was noted.
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The cranial compartment contributed 37% and the spinal compartment 63% to the total compliance of the craniospinal space in the horizontal body position. In the erect position the values were almost reversed, the cranial compartment contributing 66% and the spinal compartment 34%. The total compliance was almost unaffected by body position. ⋯ The volume of CSF moving between the cranial and spinal compartments when sitting up and lying down, was about 3 ml. The pulsatile and postural flow rate of CSF may reach about 200 ml/min. High CSF flow velocity may impair the protective coating of CSF around the brain and thus contribute to herniation.